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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: While most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drugresistance.This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatWe discuss the development of sequential drug therapies in which the first therapy is not given with

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax and antifolate resistance-associatedgenes were used for drug resistance surveillance.This study indicated that the antifolate resistance levels of P. vivax parasites were differentacross China and molecular markers could be used to rapidly monitor drug resistance.Results provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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Detection of AmpC β-lactamase and drug resistance of

Rong WANG, Shangwei WU, Xue LI, Ping HE, Yunde LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 72-75 doi: 10.1007/s11684-009-0004-y

Abstract: In order to provide useful information for effective control and clinical therapy of infection, the resistanceBy VITEK (Bacterial automatic biochemical analyzer), the isolates of were identified and the drug resistanceAmpC enzyme was detected by the five-disk diffusion test.Antibiotic sensitivity test showed that the resistanceMost of are multi-drug resistant strains.

Keywords： Enterobacter cloacae     AmpC β-lactamase     drug resistance    

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcomaIdentifying the relevant factors that drive metastasis and drug resistance is the key to improving the

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Antibiotic resistome of : molecular determinants for the emergence of drug resistance

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 693-703 doi: 10.1007/s11684-020-0777-6

Abstract: Resistome governs essential and separate biological functions to develop resistance against antibioticsAt present, the emergence of drug resistance because of resistome is a significant problem faced by cliniciansPubMed, MEDLINE, and Google Scholar with related key terms (resistome, Salmonella, antibiotics, drugresistance) and prepared this review.In this review, we summarize the status of resistance against antibiotics in S. typhi, highlight

Keywords： S. typhi     antibiotic resistance     mechanism     resistome     identification methods    

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Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou

Yan Yang, Jian Chen, Di Lin, Xujian Xu, Jun Cheng, Changgui Sun

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 182-188 doi: 10.1007/s11684-017-0529-4

Abstract: based on 242 CRE strains from a tertiary hospital in Hangzhou, China to investigate prevalence and drugresistance characteristics of CRE in southeast China.All strains exhibited high resistance (>70%) against β-lactam antibiotics, ciprofloxacin, trimethoprim–sulfamethoxazole, and nitrofurantoin but exhibited low resistance against tigecycline (0.8%) and

Keywords： Enterobacteriaceae     carbapenem     β-lactamase genes     phylogenetic analysis    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: mechanisms involved in glioma progression, including tumor heterogeneity, the tumor microenvironment and drugresistance, and their pre-clinical implements in clinical trials.

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract: factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistanceand FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drugrole and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drugaction and resistance in patients, and provide new insights into the design of novel therapeutic strategyand reliable biomarkers for prediction of drug sensitivity.

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract:

Drug resistance is a major factor that limits the efficacy of targeted cancer therapies.In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitorsHere we focus on bypass track resistance, which involves the activation of alternate signaling moleculesstrategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: The RET TKI-tolerated residual tumors inevitably develop resistance by secondary target mutations, acquiredlocated at the kinase solvent front site were identified as the major on-target mechanism of acquired resistanceHowever, it is likely that new TKI-adapted RET mutations will emerge to cause resistance to these next-generation

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drugresistance    

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Associations between

Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 92-97 doi: 10.1007/s11684-017-0610-z

Abstract: tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosisDrug resistance testing was conducted on all the isolates to the four first-line anti-TB drugs (isoniazidAnalysis of monoresistance, multidrug-resistant TB, and geographic distribution of drug resistance didtuberculosis Beijing genotype and drug-resistance phenotype in China.resistance.

Keywords： tuberculosis     drug resistance     genotype     molecular biology    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: models has become crucial for developing more effective therapies that target highly tumorigenic and drug-resistantHowever, the CSC-like cells exhibited resistance to gemcitabine-induced apoptosis.spheroid-forming CSC-like cells may serve as a model system for understanding the mechanism underlying the drugresistance of CSCs and for guiding the development of better therapies that can inhibit tumor growth

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drugleading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering     improved     pressure     aqueous     technique    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed

Keywords： controlled release     drug delivery     semi-solids     polymer     excipient    

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Title Author Date Type Operation

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article

Detection of AmpC β-lactamase and drug resistance of

Rong WANG, Shangwei WU, Xue LI, Ping HE, Yunde LIU

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Antibiotic resistome of : molecular determinants for the emergence of drug resistance

Journal Article

Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou

Yan Yang, Jian Chen, Di Lin, Xujian Xu, Jun Cheng, Changgui Sun

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Associations between

Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Protein microspheres for pulmonary drug delivery

Yongda SUN,

Journal Article

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Journal Article